Propofol & SZ...

[Nate]

I know that SZ can be caused by just about anything, but has anyone ever seen someone have multipule sz from propofol?

[chbare]

Nate, I have never had a patient develop seizures while sedated with Diprivan. I know that patients with seizure disorders are more prone to seizures during recovery. The most common side effect I have seen is hypotension. I know that people with low levels of zinc (major burns) can develop problems, and people with lipid metabolism problems may develop problems because Diprivan is a fatty emulsion. However, like you stated, anything can cause seizures, and you are altering your patients neurophysiology by giving Diprivan. Have you had a bad experience?

Take care,

chbare.

[Ridryder 911]

Ditto.... never seen or heard any anecdotal stories. Maybe Spock can enlighten us, since he works with this probably more on a daily basis.

R/r 911

[Nate]

I've never had a problem with, the four doctors I've asked said they have never had an issue with it.

[Doczilla]

Propofol has anti-epileptic properties. We take advantage of these when putting folks on the vent that have a high risk of seizure (closed head injury, history of seizures, etc.).

'zilla

[Nate]

Hmm, got me wondering if something else was in that drip. :?

[chbare]

Nate, are you able to talk about the situation or circumstances regarding the seizures?

Take care,

chbare.

[AZCEP]

Propofol can cause some tonic activity that mimics a seizure, but it will be short lived. Not really a common problem, but it is possible.

[Nate]

Propofol can cause some tonic activity that mimics a seizure, but it will be short lived. Not really a common problem, but it is possible.

Lasting about 15 to 30 seconds?

[AZCEP]

http://www.rxlist.com/cgi/generic2/propof_ad.htm

There is where I got the information from. It doesn't give a time frame, only that it can happen.