Just Plain Ruff Posted February 4, 2014 Author Share Posted February 4, 2014 The PDF file is in my files section. Link to comment Share on other sites More sharing options...
chbare Posted February 4, 2014 Share Posted February 4, 2014 Neat! I wonder what prompted them to pair glucagon and epi? Did they find a dramatic drop in glucose levels during cardiac arrest? I cannot speak to the authors but glucagon binds to metabotropic receptors and this causes an increase in an intracellular secondary messenger molecule called cAMP. This molecule have cardiovascular effects, so asking theses questions based on the known physiology associated with glucagon administration could be a starting point for researchers as there are documented cardiovascular effects associated with glucagon. Link to comment Share on other sites More sharing options...
ERDoc Posted February 4, 2014 Share Posted February 4, 2014 I cannot speak to the authors but glucagon binds to metabotropic receptors and this causes an increase in an intracellular secondary messenger molecule called cAMP. This molecule have cardiovascular effects, so asking theses questions based on the known physiology associated with glucagon administration could be a starting point for researchers as there are documented cardiovascular effects associated with glucagon. Or two grad students had a moment of ethanol-induced philosophical clarity one night and one of them remembered to write down their theory so they could present it to their department at the meeting on Monday. Link to comment Share on other sites More sharing options...
Just Plain Ruff Posted February 4, 2014 Author Share Posted February 4, 2014 I remember in the movie with Val Kilmer where he was the Genius and he was sitting under the fridge and the frozen whatchamacallit dropped out and he had his epiphany, not sure of the movie but it was one of my favorites. Or In Indpendence Day when Jeff Goldblum figured out to give the aliens the common cold. Link to comment Share on other sites More sharing options...
paramedicmike Posted February 4, 2014 Share Posted February 4, 2014 Real Genius. 1985. Link to comment Share on other sites More sharing options...
scubanurse Posted February 5, 2014 Share Posted February 5, 2014 Or two grad students had a moment of ethanol-induced philosophical clarity one night and one of them remembered to write down their theory so they could present it to their department at the meeting on Monday. I knew it had cardio effects since it's used in beta-blocker overdoses. I'll read the study though, thanks for the post Ruff! Link to comment Share on other sites More sharing options...
chbare Posted February 5, 2014 Share Posted February 5, 2014 Remember, epinephrine attaches to receptors that also use cAMP as a secondary intracellular messenger, therefore it's not unreasonable to question the physiology of other agents that make use of this molecule. Link to comment Share on other sites More sharing options...
Caduceus Posted February 5, 2014 Share Posted February 5, 2014 Hm, interesting. It's always surprising what they come up with next; it might be something that changes medicine or doesn't go beyond a small study. Link to comment Share on other sites More sharing options...
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