Adenosine - your weekly pharmacology topic

[tskstorm]

Since no one seems to believe me.

"Arrhythmias at Time of Conversion

At the time of conversion to normal sinus rhythm, a variety of new rhythms may appear on the electrocardiogram. They generally last only a few seconds without intervention, and may take the form of premature ventricular contractions, atrial premature contractions, sinus bradycardia, sinus tachycardia[/font:ad6d6be944], skipped beats, and varying degrees of A-V nodal block. Such findings were seen in 55% of patients."

http://www.rxlist.com/cgi/generic/adenos_wcp.htm < site

[ccmedoc]

RVR?

Rapid ventricular response

[AZCEP]

It is not a matter of believing you tsk, it is entirely understanding how the pathophysiology works when managed with this particular agent.

Due to it's short half-life, the effects on the AV node typically don't last very long. Because of the slowing of conduction, the initial response will be one of a bradydysrhythmia. Following the elimination of the drug, the AV node will be return to it's original ability to conduct impulses. When the heart is inadequately perfused for a period, it's first response will be to increase the rate.

Sinus tachycardia is not pharmacologically possible from administration of adenosine, but is relatively common following it's use.

[AnthonyM83]

That was very educational for me. That's kind of stuff I like learning about. I can make my flashcards and lookup the indications, contraindications, and mechanism of action online, but understanding the theory and process of how it works is what I'm really looking for.