Blood clotting agent
Posted 31 May 2006 - 04:40 AM
Posted 31 May 2006 - 05:15 AM
I hope this helps. Take care,
Posted 31 May 2006 - 05:59 AM
My guess is that they are talking about clotting Factor VIIa. There are a couple of studies still underway, I believe, regarding the use of clotting Factor VIIa in traumatic hæmorrhage. I'm not sure where those are. There have already been a couple of studies, but they were not well controlled, rendering the results inconclusive. And those results suggest there is no difference in mortality or morbidity between those who receive it and those who do not. It is not licensed for such use, but it is sometimes tried in desperation anyhow, and with the study results pending, it still comes up in discussion.
Even the most rudimentary understanding of human physiology tells us that there are problems with such a product. First of all, when you start encouraging clotting, you start encouraging emboli and circulatory problems. Stopping bleeding isn't a real victory if you create mortal pulmonary or cerebral emboli in the process. Second, clotting factors work by activating platelets ability to aggregate. If you are already significantly hypovolemic, you don't have enough platelets to complete the process. There is nothing left to activate. And, in the case of the JW victim you are referring to, she's not going to allow any platelets to be infused, so quite likely she would see little if any benefit from infusion of clotting factor. Kinda like gas treatment in a car that has no gas. And of course, Factor VIIa is synthesized from blood components to begin with, so she still probably isn't going to accept it if the physician is honest with her.
Posted 31 May 2006 - 10:05 PM
THe show was based in baltimore, md at shock trauma. The lady had a subdural. They made the comment that it (clotting factor) would be short term fix, but that they could not take her to surgery without being able to give her blood. The lady ended up dying. I am not familiar with the factor 8 - but thanks for the insight. I was under the impression that you wouldn't use a colloid (other than whole blood) in a head injury. THis is a major contraindication with the polyheme (I refer to that as my service is involved with the trial - so I am most educated about it than other options). Thanks for the input.
Posted 31 May 2006 - 10:25 PM
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