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Do you give benzo's to a hypoglycemic seizure?


vs-eh?

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In reading the posts I'm hearing a lot about treating the underlying cause, which makes sense since that has been drilled into out heads with ACLS. So, let me make an analogy to ACLS. You have a pt in a PEA which could be caused by a number of underlying conditions {PATCH(4)MD}. You eventually want to treat those underlying conditions so that the PEA doesn't continue or come back, however, you still have a pt who has no airway, no pulse and no breathing. Before you can treat any underlying cause (unless it's hypoxia) you have to get your ABC's out of the way.

As it is with an active seizure, you don't have a secure airway. The best way to get one would be to stop the seizure (versed intranasally would be very nice as it is fast acting and has a relatively short half-life). You now have a nice shot at an IV and assuming that your seizure was caused by the hypoglycemia you can go ahead with D50.

Glucagon IM takes awhile and I would not want to be sitting around on scene waiting while my pt continues to thrash around without an airway.

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In my earlier post, I stated that my preference would be to break the seizure first - and then follow with glucose check to confirm or rule out hypoglycemia.

Ace is right - every patient should get the same thorough evaluation, regardless of what you know (or think you know) about a patient. Providing care based solely on a bracelet or on the word of a bystander will eventually get you into trouble. How many causes for seizure can you think of - hypoxia, hypoglycemia, fever, toxins, cva, tumor, etc. Evaluation done properly is a scientific method of examining all possibilities and systematically ruling them in or out. The presenting problem is an active seizure - break the seizure and then work to determine and treat the cause of the presenting problem.

Remember the common test question about a driver observed operating erratically who crashes into a pole and is found acting "intoxicated"?? Are his actions the cause of the crash (medical, ETOH), or did the crash cause his current state (head trauma)?? Which came first - the chicken or the egg??

Hi all,

"buddha", thanks for helping to illustrate the point here which is in short. Not always is the presenting symptom or underlying disorder the zebra in a herd of horses, but if you take all the horses away and are left with a zebra....then.... :roll: :idea: then your clue phone should ring!!!

out here,

Ace844

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Thanks ditch doctor. I know what I'm looking at now. I have never heard of lorazapam called anything but lorazapam. The most common trade name for midazalam over here is hypnoval but is usually just called midazolam.

Thanks

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You gotta get the IV then stop the seizures. You are not able to give gluecagon to a seizure pt. To much possibility of them choking on it then you have another problem to worry about. I would TX the seizure then the hypoglycemia.

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You gotta get the IV then stop the seizures. You are not able to give gluecagon to a seizure pt. To much possibility of them choking on it then you have another problem to worry about. I would TX the seizure then the hypoglycemia.

Hi "ardolphin26",

Just incase you were unaware, when the poster was referring to Glucagon they were referring to the IM medicine, not the "sugar in a tube" to which you were referring. here's more info on glucagon in case you don't have access and here's a link to check as well. http://www.drugs.com/PDR/Glucagon_for_Inje...rgency_Kit.html

Hope this helps,

Ace844

PDR Drug information for

Glucagon for Injection Vials and Emergency Kit

Manufacturer: Lilly

INFORMATION FOR THE PHYSICIAN

DESCRIPTION

Glucagon for Injection (rDNA origin) is a polypeptide hormone identical to human glucagon that increases blood glucose and relaxes smooth muscle of the gastrointestinal tract. Glucagon is synthesized in a special non-pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for glucagon.

Glucagon is a single-chain polypeptide that contains 29 amino acid residues and has a molecular weight of 3,483.

The empirical formula is C 153 H 225 N 43 O 49 S. The primary sequence of glucagon is shown below.

Crystalline glucagon is a white to off-white powder. It is relatively insoluble in water but is soluble at a pH of less than 3 or more than 9.5.

Glucagon is available for use intravenously, intramuscularly, or subcutaneously in a kit that contains a vial of sterile glucagon and a syringe of sterile diluent. The vial contains 1 mg (1 unit) of glucagon and 49 mg of lactose. Hydrochloric acid may have been added during manufacture to adjust the pH of the glucagon. One International Unit of glucagon is equivalent to 1 mg of glucagon. 1 The diluent syringe contains 12 mg/mL of glycerin, water for injection, and hydrochloric acid.

CLINICAL PHARMACOLOGY

Glucagon increases blood glucose concentration and is used in the treatment of hypoglycemia. Glucagon acts only on liver glycogen, converting it to glucose.

Glucagon administered through a parenteral route relaxes smooth muscle of the stomach, duodenum, small bowel, and colon.

Pharmacokinetics

Glucagon has been studied following intramuscular, subcutaneous, and intravenous administration in adult volunteers. Administration of the intravenous glucagon showed dose proportionality of the pharmacokinetics between 0.25 and 2.0 mg. Calculations from a 1 mg dose showed a small volume of distribution (mean, 0.25 L/kg) and a moderate clearance (mean, 13.5 mL/min/kg). The half-life was short, ranging from 8 to 18 minutes.

Maximum plasma concentrations of 7.9 ng/mL were achieved approximately 20 minutes after subcutaneous administration ( see Figure 1A ). With intramuscular dosing, maximum plasma concentrations of 6.9 ng/mL were attained approximately 13 minutes after dosing.

Glucagon is extensively degraded in liver, kidney, and plasma. Urinary excretion of intact glucagon has not been measured.

Pharmacodynamics

In a study of 25 volunteers, a subcutaneous dose of 1 mg glucagon resulted in a mean peak glucose concentration of 136 mg/dL 30 minutes after injection ( see Figure 1B ). Similarly, following intramuscular injection, the mean peak glucose level was 138 mg/dL, which occurred at 26 minutes after injection. No difference in maximum blood glucose concentration between animal-sourced and rDNA glucagon was observed after subcutaneous and intramuscular injection.

INDICATIONS AND USAGE

For the treatment of hypoglycemia:

Glucagon is indicated as a treatment for severe hypoglycemia.

Because patients with type 1 diabetes may have less of an increase in blood glucose levels compared with a stable type 2 patient, supplementary carbohydrate should be given as soon as possible, especially to a pediatric patient.

For use as a diagnostic aid:

Glucagon is indicated as a diagnostic aid in the radiologic examination of the stomach, duodenum, small bowel, and colon when diminished intestinal motility would be advantageous.

Glucagon is as effective for this examination as are the anticholinergic drugs. However, the addition of the anticholinergic agent may result in increased side effects.

CONTRAINDICATIONS

Glucagon is contraindicated in patients with known hypersensitivity to it or in patients with known pheochromocytoma.

WARNINGS

Glucagon should be administered cautiously to patients with a history suggestive of insulinoma, pheochromocytoma, or both. In patients with insulinoma, intravenous administration of glucagon may produce an initial increase in blood glucose; however, because of glucagon's hyperglycemic effect the insulinoma may release insulin and cause subsequent hypoglycemia. A patient developing symptoms of hypoglycemia after a dose of glucagon should be given glucose orally, intravenously, or by gavage, whichever is most appropriate.

Exogenous glucagon also stimulates the release of catecholamines. In the presence of pheochromocytoma, glucagon can cause the tumor to release catecholamines, which may result in a sudden and marked increase in blood pressure. If a patient develops a sudden increase in blood pressure, 5 to 10 mg of phentolamine mesylate may be administered intravenously in an attempt to control the blood pressure.

Generalized allergic reactions, including urticaria, respiratory distress, and hypotension, have been reported in patients who received glucagon by injection.

PRECAUTIONS

General-- Glucagon is effective in treating hypoglycemia only if sufficient liver glycogen is present. Because glucagon is of little or no help in states of starvation, adrenal insufficiency, or chronic hypoglycemia, hypoglycemia in these conditions should be treated with glucose.

Information for Patients-- Refer patients and family members to the attached Information for the User for instructions describing the method of preparing and injecting glucagon. Advise the patient and family members to become familiar with the technique of preparing glucagon before an emergency arises. Instruct patients to use 1 mg (1 unit) for adults and 1/2 the adult dose (0.5 mg) [0.5 unit] for pediatric patients weighing less than 44 lb (20 kg).

Patients and family members should be informed of the following measures to prevent hypoglycemic reactions due to insulin:

Reasonable uniformity from day to day with regard to diet, insulin, and exercise.

Careful adjustment of the insulin program so that the type (or types) of insulin, dose, and time (or times) of administration are suited to the individual patient.

Frequent testing of the blood or urine for glucose so that a change in insulin requirements can be foreseen.

Routine carrying of sugar, candy, or other readily absorbable carbohydrate by the patient so that it may be taken at the first warning of an oncoming reaction.

To prevent severe hypoglycemia, patients and family members should be informed of the symptoms of mild hypoglycemia and how to treat it appropriately.

Family members should be informed to arouse the patient as quickly as possible because prolonged hypoglycemia may result in damage to the central nervous system. Glucagon or intravenous glucose should awaken the patient sufficiently so that oral carbohydrates may be taken.

Patients should be advised to inform their physician when hypoglycemic reactions occur so that the treatment regimen may be adjusted if necessary.

Laboratory Tests-- Blood glucose determinations should be obtained to follow the patient with hypoglycemia until patient is asymptomatic.

Carcinogenesis, Mutagenesis, Impairment of Fertility-- Because glucagon is usually given in a single dose and has a very short half-life, no studies have been done regarding carcinogenesis. In a series of studies examining effects on the bacterial mutagenesis (Ames) assay, it was determined that an increase in colony counts was related to technical difficulties in running this assay with peptides and was not due to mutagenic activities of the glucagon.

Reproduction studies have been performed in rats at doses up to 2 mg/kg glucagon administered two times a day (up to 40 times the human dose based on body surface area, mg/m 2 ) and have revealed no evidence of impaired fertility.

Pregnancy--Pregnancy Category B-- Reproduction studies have not been performed with recombinant glucagon. However, studies with animal-sourced glucagon were performed in rats at doses up to 2 mg/kg glucagon administered two times a day (up to 40 times the human dose based on body surface area, mg/m 2 ), and have revealed no evidence of impaired fertility or harm to the fetus due to glucagon. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Nursing Mothers- - It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when glucagon is administered to a nursing woman. If the drug is excreted in human milk during its short half-life, it will be hydrolyzed and absorbed like any other polypeptide. Glucagon is not active when taken orally because it is destroyed in the gastrointestinal tract before it can be absorbed.

Pediatric Use- - For the treatment of hypoglycemia: The use of glucagon in pediatric patients has been reported to be safe and effective. 2-6

For use as a diagnostic aid: Effectiveness has not been established in pediatric patients.

ADVERSE REACTIONS

Severe adverse reactions are very rare, although nausea and vomiting may occur occasionally. These reactions may also occur with hypoglycemia. Generalized allergic reactions have been reported ( see WARNINGS ). In a three month controlled study of 75 volunteers comparing animal-sourced glucagon with glucagon manufactured through rDNA technology, no glucagon-specific antibodies were detected in either treatment group.

OVERDOSAGE

Signs and Symptoms-- If overdosage occurs, nausea, vomiting, gastric hypotonicity, and diarrhea would be expected without causing consequential toxicity.

Intravenous administration of glucagon has been shown to have positive inotropic and chronotropic effects. A transient increase in both blood pressure and pulse rate may occur following the administration of glucagon. Patients taking (beta)-blockers might be expected to have a greater increase in both pulse and blood pressure, an increase of which will be transient because of glucagon's short half-life. The increase in blood pressure and pulse rate may require therapy in patients with pheochromocytoma or coronary artery disease.

When glucagon was given in large doses to patients with cardiac disease, investigators reported a positive inotropic effect. These investigators administered glucagon in doses of 0.5 to 16 mg/hour by continuous infusion for periods of 5 to 166 hours. Total doses ranged from 25 to 996 mg, and a 21-month-old infant received approximately 8.25 mg in 165 hours. Side effects included nausea, vomiting, and decreasing serum potassium concentration. Serum potassium concentration could be maintained within normal limits with supplemental potassium.

The intravenous median lethal dose for glucagon in mice and rats is approximately 300 mg/kg and 38.6 mg/kg, respectively.

Because glucagon is a polypeptide, it would be rapidly destroyed in the gastrointestinal tract if it were to be accidentally ingested.

Treatment-- To obtain up-to-date information about the treatment of overdose, a good resource is your certified Regional Poison Control Center. Telephone numbers of certified poison control centers are listed in the Physicians' Desk Reference (PDR) . In managing overdosage, consider the possibility of multiple drug overdoses, interaction among drugs, and unusual drug kinetics in your patient.

In view of the extremely short half-life of glucagon and its prompt destruction and excretion, the treatment of overdosage is symptomatic, primarily for nausea, vomiting, and possible hypokalemia.

If the patient develops a dramatic increase in blood pressure, 5 to 10 mg of phentolamine mesylate has been shown to be effective in lowering blood pressure for the short time that control would be needed.

Forced diuresis, peritoneal dialysis, hemodialysis, or charcoal hemoperfusion have not been established as beneficial for an overdose of glucagon; it is extremely unlikely that one of these procedures would ever be indicated.

DOSAGE AND ADMINISTRATION

General Instructions for Use:

The diluent is provided for use only in the preparation of glucagon for parenteral injection and for no other use.

Glucagon should not be used at concentrations greater than 1 mg/mL (1 unit/mL).

Reconstituted glucagon should be used immediately. Discard any unused portion.

Reconstituted glucagon solutions should be used only if they are clear and of a water-like consistency.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.

Directions for Treatment of Severe Hypoglycemia:

Severe hypoglycemia should be treated initially with intravenous glucose, if possible.

If parenteral glucose can not be used, dissolve the lyophilized glucagon using the accompanying diluting solution and use immediately.

For adults and for pediatric patients weighing more than 44 lb (20 kg), give 1 mg (1 unit) by subcutaneous, intramuscular, or intravenous injection.

For pediatric patients weighing less than 44 lb (20 kg), give 0.5 mg (0.5 unit) or a dose equivalent to 20-30 µg/kg. 2-6

Discard any unused portion.

An unconscious patient will usually awaken within 15 minutes following the glucagon injection. If the response is delayed, there is no contraindication to the administration of an additional dose of glucagon; however, in view of the deleterious effects of cerebral hypoglycemia emergency aid should be sought so that parenteral glucose can be given.

After the patient responds, supplemental carbohydrate should be given to restore liver glycogen and to prevent secondary hypoglycemia.

Directions for Use as a Diagnostic Aid:

Dissolve the lyophilized glucagon using the accompanying diluting solution and use immediately. Discard any unused portion.

The doses in the following table may be administered for relaxation of the stomach, duodenum, and small bowel, depending on the onset and duration of effect required for the examination. Since the stomach is less sensitive to the effect of glucagon, 0.5 mg (0.5 units) IV or 2 mg (2 units) IM are recommended.

Dose Route of

Administration Time of Onset of

Action Approximate

Duration of Effect

0.25-0.5 mg IV 1 minute 9-17 minutes

(0.25-0.5 units)

1 mg (1 unit) IM 8-10 minutes 12-27 minutes

2 mg * (2 units) IV 1 minute 22-25 minutes

2 mg * (2 units) IM 4-7 minutes 21-32 minutes

*Administration of 2 mg (2 units) doses produces a higher incidence of nausea and vomiting than do lower doses.

For examination of the colon, it is recommended that a 2 mg (2 units) dose be administered intramuscularly approximately 10 minutes prior to the procedure. Colon relaxation and reduction of patient discomfort may allow the radiologist to perform a more satisfactory examination.

HOW SUPPLIED

Glucagon Emergency Kit for Low Blood Sugar (Glucagon for

Injection [rDNA origin]) (MS8031):

1 mg (1 unit)--(VL7529), with 1 mL of diluting solution

(Hyporet® * HY7530) (1s)

NDC 0002-8031-01

Glucagon Diagnostic Kit (Glucagon for Injection [rDNA ori-

gin]) (MS8085):

1 mg (1 unit)--(VL7529), with 1 mL of diluting solution

(Hyporet® * HY7530) (1s)

NDC 0002-8085-01 (available in US market only).

--------------------------------------------------------------------------------

*Hyporet® (disposable syringe, Lilly).

Stability and Storage:

Before Reconstitution --Vials of Glucagon, as well as the Diluting Solution for Glucagon, may be stored at controlled room temperature 20° to 25°C (68° to 77°F)[see USP].

The USP defines controlled room temperature by the following: A temperature maintained thermostatically that encompasses the usual and customary working environment of 20° to 25°C (68° to 77°F); that results in a mean kinetic temperature calculated to be not more than 25°C; and that allows for excursions between 15° and 30°C (59° and 86°F) that are experienced in pharmacies, hospitals, and warehouses.

After Reconstitution --Glucagon for Injection (rDNA origin) should be used immediately. Discard any unused portion.

REFERENCES

Drug Information for the Health Care Professional. 18th ed. Rockville, Maryland: The United States Pharmacopeial Convention, Inc; 1998; I:1512.

Gibbs et al: Use of glucagon to terminate insulin reactions in diabetic children. Nebr Med J 1958;43:56-57.

Cornblath M, et al: Studies of carbohydrate metabolism in the newborn: Effect of glucagon on concentration of sugar in capillary blood of newborn infant. Pediatrics 1958;21:885-892.

Carson MJ, Koch R: Clinical studies with glucagon in children. J Pediatr 1955;47:161-170.

Shipp JC, et al: Treatment of insulin hypoglycemia in diabetic campers. Diabetes 1964;13:645-648.

Aman J, Wranne L: Hypoglycemia in childhood diabetes II: Effect of subcutaneous or intramuscular injection of different doses of glucagon. Acta Pediatr Scand 1988;77:548-553.

Literature revised April 27, 2001

PA 2282 AMP

Copyright © 1999, 2001, Eli Lilly and Company. All rights reserved.

INFORMATION FOR THE USER

GLUCAGON

FOR INJECTION

(rDNA ORIGIN)

BECOME FAMILIAR WITH THE FOLLOWING INSTRUCTIONS BEFORE AN EMERGENCY ARISES. DO NOT USE THIS KIT AFTER DATE STAMPED ON THE BOTTLE LABEL. IF YOU HAVE QUESTIONS CONCERNING THE USE OF THIS PRODUCT, CONSULT A DOCTOR, NURSE OR PHARMACIST.

Make sure that your relatives or close friends know that if you become unconscious, medical assistance must always be sought. Glucagon may have been prescribed so that members of your household can give the injection if you become hypoglycemic and are unable to take sugar by mouth. If you are unconscious, glucagon can be given while awaiting medical assistance.

Show your family members and others where you keep this kit and how to use it. They need to know how to use it before you need it. They can practice giving a shot by giving you your normal insulin shots. It is important that they practice. A person who has never given a shot probably will not be able to do it in an emergency.

IMPORTANT

Act quickly. Prolonged unconsciousness may be harmful.

These simple instructions will help you give glucagon successfully.

Turn patient on his/her side to prevent patient from choking.

The contents of the syringe are inactive. You must mix the contents of the syringe with the glucagon in the accompanying bottle before giving injection. (See DIRECTIONS FOR USE below.)

Do not prepare Glucagon for Injection until you are ready to use it.

WARNING: THE PATIENT MAY BE IN A COMA FROM SEVERE HYPERGLYCEMIA (HIGH BLOOD GLUCOSE) RATHER THAN HYPOGLYCEMIA. IN SUCH A CASE, THE PATIENT WILL NOT RESPOND TO GLUCAGON AND REQUIRES IMMEDIATE MEDICAL ATTENTION.

INDICATIONS FOR USE

Use glucagon to treat insulin coma or insulin reaction resulting from severe hypoglycemia (low blood sugar). Symptoms of severe hypoglycemia include disorientation, unconsciousness, and seizures or convulsions. Give glucagon if (1) the patient is unconscious (2) the patient is unable to eat sugar or a sugar-sweetened product (3) the patient is having a seizure, or (4) repeated administration of sugar or a sugar-sweetened product such as a regular soft drink or fruit juice does not improve the patient's condition. Milder cases of hypoglycemia should be treated promptly by eating sugar or a sugar-sweetened product. (See INFORMATION ON HYPOGLYCEMIA below for more information on the symptoms of hypoglycemia.) Glucagon is not active when taken orally.

DIRECTIONS FOR USE

TO PREPARE GLUCAGON FOR INJECTION

Remove the flip-off seal from the bottle of glucagon. Wipe rubber stopper on bottle with alcohol swab.

Remove the needle protector from the syringe, and inject the entire contents of the syringe into the bottle of glucagon. DO NOT REMOVE THE PLASTIC CLIP FROM THE SYRINGE. Remove syringe from the bottle.

Swirl bottle gently until glucagon dissolves completely. GLUCAGON SHOULD NOT BE USED UNLESS THE SOLUTION IS CLEAR AND OF A WATER-LIKE CONSISTENCY.

TO INJECT GLUCAGON

Use Same Technique as for Injecting Insulin

Using the same syringe, hold bottle upside down and, making sure the needle tip remains in solution, gently withdraw all of the solution (1 mg mark on syringe) from bottle. The plastic clip on the syringe will prevent the rubber stopper from being pulled out of the syringe; however, if the plastic plunger rod separates from the rubber stopper, simply reinsert the rod by turning it clockwise. The usual adult dose is 1 mg (1 unit). For children weighing less than 44 lb (20 kg), give 1/2 adult dose (0.5 mg). For children, withdraw 1/2 of the solution from the bottle (0.5 mg mark on syringe). DISCARD UNUSED PORTION.

USING THE FOLLOWING DIRECTIONS,

INJECT GLUCAGON IMMEDIATELY AFTER MIXING.

Cleanse injection site on buttock, arm, or thigh with alcohol swab.

Insert the needle into the loose tissue under the cleansed injection site, and inject all (or ½ for children weighing less than 44 lb) of the glucagon solution. THERE IS NO DANGER OF OVERDOSE. Apply light pressure at the injection site, and withdraw the needle. Press an alcohol swab against the injection site.

Turn the patient on his/her side. When an unconscious person awakens, he/she may vomit. Turning the patient on his/her side will prevent him/her from choking.

FEED THE PATIENT AS SOON AS HE/SHE AWAKENS AND IS ABLE TO SWALLOW. Give the patient a fast-acting source of sugar (such as a regular soft drink or fruit juice) and a long-acting source of sugar (such as crackers and cheese or a meat sandwich). If the patient does not awaken within 15 minutes, give another dose of glucagon and INFORM A DOCTOR OR EMERGENCY SERVICES IMMEDIATELY.

Even if the glucagon revives the patient, his/her doctor should be promptly notified. A doctor should be notified whenever severe hypoglycemic reactions occur.

INFORMATION ON HYPOGLYCEMIA

Early symptoms of hypoglycemia (low blood glucose) include:

sweating

dizziness

palpitation

tremor

hunger

restlessness

tingling in the hands, feet, lips, or tongue

lightheadedness

inability to concentrate

headache

drowsiness

sleep disturbances

anxiety

blurred vision

slurred speech

depressed mood

irritability

abnormal behavior

unsteady movement

personality changes

If not treated, the patient may progress to severe hypoglycemia that can include:

disorientation

unconsciousness

seizures

death

The occurrence of early symptoms calls for prompt and, if necessary, repeated administration of some form of carbohydrate. Patients should always carry a quick source of sugar, such as candy mints or glucose tablets. The prompt treatment of mild hypoglycemic symptoms can prevent severe hypoglycemic reactions. If the patient does not improve or if administration of carbohydrate is impossible, glucagon should be given or the patient should be treated with intravenous glucose at a medical facility. Glucagon, a naturally occurring substance produced by the pancreas, is helpful because it enables the patient to produce his/her own blood glucose to correct the hypoglycemia.

POSSIBLE PROBLEMS WITH GLUCAGON TREATMENT

Severe side effects are very rare, although nausea and vomiting may occur occasionally.

A few people may be allergic to glucagon or to one of the inactive ingredients in glucagon, or may experience rapid heart beat for a short while.

If you experience any other reactions which are likely to have been caused by glucagon, please contact your doctor.

STORAGE

Before dissolving glucagon with diluting solution--Store the kit at controlled room temperature between 20° to 25°C (68° to 77°F).

After dissolving glucagon with diluting solution--Should be used immediately. Discard any unused portion. Solutions should be clear and of a water-like consistency at time of use.

Literature revised April 27, 2001

PA 2282 AMP

Copyright © 1999, 2001, Eli Lilly and Company. All rights reserved.

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After reading these posts, I'm kind of convinced the posters are of two camps.

Camp A: Those who have treated an actively seizing patient in the field. They understand that getting IV access ain't gonna happen, and the seizure needs to stop. Buddha's analogy, very descriptively I might add, made this point.

Camp B: Those who have read about treating seizures in the textbook, and insist that treating the underlying cause is most important because that's what the book says.

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